Celsus Naphazoline HCl + Pheniramine Maleate Ophthalmic Solution Description

Naphazoline Hydrochloride: The hydrochloride salt form of naphazoline, an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive properties. Upon ocular administration, Naphazoline hydrochloride exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation, and redness.
Pheniramine Maleate: The maleate salt form of pheniramine, an alkylamine derivative with antihistaminic and vasodilatory properties. Pheniramine maleate binds to histamine H1 receptors, thereby inhibiting phospholipids A2 and production of endothelium-derived relaxing factor, nitric oxide. Subsequent lack of activation of gauntly cycles through nitric oxide results in decreased cyclic GMP camp levels, thereby inhibiting constriction of smooth muscle tissue, and decreased capillary permeability and histamine-activated allergic reactions.
Each mL of solution contains: Naphazoline (as HCl) 0.1 mg; Pheniramine (as maleate) 2.2 mg.
Excipients/Inactive Ingredients: Boric Acid, Sodium Chloride, Potassium Chloride, Edetate Sodium, Purified Water.
Preservative: 0.01% Benzalkonium Chloride.